Constella Linzess (Linaclotide)




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Product Details


LINZESS (Linaclotide) is a medication prescribed to either irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC). Patients with IBS-C and CIC have chronic symptoms of constipation and reduced passage of stool.

LINZESS works by attaching to guanylate cyclase-C (GC-C) on the surface of intestinal epithelium cells. The activation of GC-C receptors increases the compound cyclic guanosine monophosphate, which causes intestinal cells to excrete chloride and bicarbonate and pull fluid into the intestinal space. LINZESS may also help to stop muscle contractions of the abdomen that cause pain.

How long does it take LINZESS to work? Most patients have maximum relief of constipation by the second week of treatment.


Your doctor will prescribe a LINZESS dosage based on which condition is being treated. The usual dosages are:

  • IBC-C: 290 micrograms (mcg) by mouth once daily
  • CIC: 72 to 145 mcg by mouth once daily

Take LINZESS on an empty stomach at least 30 minutes before the first meal of the day. Do not crush, chew, or open LINZESS capsules; swallow whole.


The active ingredient in LINZESS is linaclotide.


The most common side effect while taking LINZESS is diarrhea, which can be severe in some patients. Patients with diarrhea have a high risk of dehydration while taking LINZESS. Symptoms of dehydration may include fainting, dizziness, low blood pressure, and electrolyte abnormalities.

If you overdose and experience serious side effects and symptoms call your nearest doctor or pharmacist as soon as possible, it may have serious effects on your body. Keep these capsules at room temperature and away from moisture and heat.

Side Effects

Some of the most common adverse reactions from LINZESS may include:

  • Abdominal Distension
  • Abdominal Pain
  • Diarrhea
  • Flatulence
  • Headache
  • Viral Gastroenteritis

If you experience severe diarrhea while taking LINZESS, tell your doctor. You may need to pause taking the medication. Ensure that you are hydrating during any and all episodes of diarrhea.