Cuprimine (Penicillamine)




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Cuprimine Drug Information

Chemical Name: PENICILLAMINE (pen-i-SILL-a-meen)

Cuprimine (Penicillamine)

Cuprimine is a chelating agent. It is used in the treatment of rheumatoid arthritis, Wilson’s disease (high levels of copper in the body causing damage to liver, brain and other organs) and cystinuria which causes the formation of kidney stones.

For treating rheumatoid arthritis, penicillamine is known as DMARD (disease modifying anti-rheumatic drug). It reduces pain, tenderness, and swelling in the joints. But Cuprimine is not used to treat juvenile rheumatoid arthritis.

For treating Wilson’s disease, penicillamine binds with excess copper and removes it from the body. Decreasing the levels of copper improves liver function and mental, mood or nerve problems manifested as confusion, difficulty in walking, and speaking.

For treating cystinuria, penicillamine reduces the levels of amino acid, cysteine in urine thus lowering the chances of developing kidney stones.

Cuprimine is easily available, and you can go ahead and buy Cuprimine online from Canada Pharmacy.


Cuprimine dosage should be strictly followed as prescribed by your doctor. Usually, Cuprimine is taken on an empty stomach, at least 1 hour before or 2 hours after a meal. Do not drink milk or take antacids or food 1 hour before or 1 hour after you take Cuprimine. Furthermore, take large quantities of fluid with Cuprimine. It may take 2 to 3 months before you might start seeing any improvement in the prescribed condition.

Your doctor might also add multivitamins or extra iron or vitamin B6 with Cuprimine intake. Only take the supplements advised by your doctor.


The active ingredient (comes in 2 strengths):

  • Penicillamine 125 mg
  • Penicillamine 250 mg


Before taking Cuprimine, consult your doctor if you have:

  • Liver disease
  • Allergy to penicillin
  • Stomach ulcers
  • Weak immune system
  • Malnourished
  • Pregnancy
  • Breastfeeding
  • Using gold injections

Side Effects

In case of adverse effects, immediately consult your doctor. Side effects associated with Cuprimine are as follows:

  • Sudden fever
  • Skin rash
  • Joint pain
  • Swollen glands
  • Easy bruising or bleeding
  • Sudden weakness
  • Sore throat
  • Mouth or skin sores, red or swollen gums
  • Swelling of hands, legs, or feet
  • Pain or burning when urinating, foamy or bloody urine, lower backache
  • Lightheadedness, shortness of breath
  • Muscle weakness in the face, double vision, drooping eyelids
  • Nausea, vomiting, stomach pain, loss of appetite
  • Ringing in ears
  • Inability of the wound to heal