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Invega Sustenna ( Paliperidone )


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Invega Sustenna (Paliperidone)

Medication Information


Invega is an atypical antipsychotic that is used to treat schizophrenia and schizoaffective disorder.

Side Effects

The most common side effects of Invega include:

  • Extrapyramidal symptoms
  • Tachycardia
  • Akathisia
  • Somnolence
  • Constipation
  • Weight gain
  • Dyspepsia

Speak with your doctor for a full list of side effects that apply to you if you are taking Paliperidone.


There is risk of movement disorders, like tardive dyskinesia with Invega, if this occurs you should stop treatment.

There is a risk of QTc prolongation and orthostatic hypotension when taking Invega, so heart function should be monitored.

There is a risk of low blood counts when taking Paliperidone, your blood should be monitored while taking this medication.


The most common drug interactions with Invega include:

  • Alcohol
  • Carbamazepine
  • Divalproex

Speak with your doctor for more information and before starting a new medication with Paliperidone.


Store at room temperature (77 ºF). Protect from moisture.

Pharmacist Tips

  • Invega can cause a decrease in blood pressure with positional changes, so be careful when first taking this medicine.
  • Invega like other antipsychotics can cause movement disorders, if these occur let your doctor know.
  • Paliperidone should be taken in the morning with or without food.

Paliperidone FAQs

How long does it take for Invega to work?

It can take a few weeks, to see any effect with Invega, and up to several months to see the full benefit.


How does Invega Sustenna make you feel?

Common side effects with Paliperidone include somnolence, weight gain, and abnormal movements.


Does Invega cause memory loss?

Invega can cause memory loss.


Does Invega treat bipolar disorder?

Paliperidone does not have an FDA indication to treat bipolar disorder.


Is Invega a mood stabilizer?

Yes, Invega is common referred to as a mood stabilizer.

Related Drugs

  • Abilify
  • Geodon
  • Latuda
  • Seroquel
  • ZyprexaIMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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