Premarin Cream (Conjugated Estrogens)




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Product Details


PREMARIN cream (conjugated estrogens) is a medication prescribed to treat atrophic vaginitis (thinning, drying, and inflammation of the vaginal walls) and kraurosis vulvae (shrinkage of the skin of the vagina and vulva). PREMARIN cream may also be prescribed to treat dyspareunia (pain or difficulty during intercourse).

After menopause, the levels of circulating estrogen decreases. Additionally, different types of estrogens are present than pre-menopause. PREMARIN works by increasing levels of the levels of certain estrogens and decreasing circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Increasing levels of estrogen help to maintain secondary sexual characteristics.


When treating atrophic vaginitis or kraurosis vulvae, the typical dosage of PREMARIN is 0.5 g once daily intravaginally for 7 days on and 21 days off. Use the included applicator to measure the appropriate dose.

When treating dyspareunia, the typical dose is 0.5 g twice weekly.


The active ingredients in PREMARIN cream are conjugated estrogens — sodium estrone sulfate, sodium equilin sulfate, 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin.

The inactive ingredients include benzyl alcohol, cetyl alcohol, cetyl esters wax, glycerin, glyceryl monostearate, mineral oil, methyl stearate, and white wax.


Estrogens have been shown to increase the risk of stroke and deep vein thrombosis (DVT) in postmenopausal women. The increased risk has been shown with daily oral estrogen supplements, and the risk is probably lower for topical formulations.

Daily oral estrogens have also been shown to increase the risk of myocardial infarction (heart attack), invasive breast cancer, pulmonary emboli, and uterine cancer. This risk is probably not as great for topical formulations.

Due to the increased risk of the above-listed health conditions, PREMARIN cream should be used for the shortest amount of time at the lowest possible dose.

Speak to your doctor for a full list of cautions before using PREMARIN cream.

Side Effects

The most common side effects of PREMARIN cream include:

  • Abdominal pain
  • Back pain
  • Mastalgia
  • Pain
  • Vaginitis
  • Vasodilation
  • Weakness