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Velcade Information

VELCADE is a prescription medicine used to treat adults with multiple myeloma and mantle cell lymphoma

What is the most important information I should know about VELCADE?

•  You should not receive VELCADE if you are allergic to bortezomib, boron, or mannitol.
•  VELCADE must not be administered into your spinal fluid (intrathecally) because of possible serious side effects that can lead to death.

What are the possible side effects of VELCADE?

VELCADE can cause serious side effects, including:

•  Nerve problems (peripheral neuropathy). VELCADE can cause damage to the nerves, a condition called peripheral neuropathy. Tell your healthcare provider if you get any new or worsening symptoms, including: muscle weakness, tingling, burning, pain, and loss of feeling in your hands and feet, any of which can be severe. Your doctor may change the dose and/or schedule of VELCADE or stop it altogether. If you have peripheral neuropathy before starting VELCADE, your doctor could consider giving you VELCADE subcutaneously.
•  Low blood pressure (hypotension). VELCADE can cause a drop in blood pressure. Tell your doctor if you have low blood pressure, feel dizzy, or feel as though you might faint. If you are taking drugs that lower blood pressure, your medications might need to be adjusted. If you are not drinking enough liquids, your doctor may need to administer IV fluids.
•  Heart problems. Treatment with VELCADE can cause or worsen heart rhythm problems and heart failure. Your doctor may closely monitor you if you have, or are at risk for, heart disease. Tell your doctor if you experience chest pressure or pain, palpitations, swelling of your ankles or feet, or shortness of breath.
•  Lung problems. There have been reports of lung disorders in people receiving VELCADE. Some of these events have been fatal. Tell your doctor if you experience any cough, shortness of breath, wheezing, or difficulty breathing.
•  Brain swelling (Posterior Reversible Encephalopathy Syndrome—PRES). There have been reports of a rare, reversible condition involving the brain, called PRES, in people treated with VELCADE. People with PRES can have seizures, high blood pressure, headaches, tiredness, confusion, blindness, or other vision problems. Treatment with VELCADE should be stopped in cases of PRES. It is not known whether restarting VELCADE therapy in patients previously experiencing this complication is safe.
•  Stomach and intestinal (gastrointestinal) problems. VELCADE treatment can cause nausea, vomiting, diarrhea, and constipation. If your symptoms are severe, your doctor may recommend IV fluids and/or medications.
•  Low platelet counts (thrombocytopenia). VELCADE can cause low levels of platelets (clot-forming cells). Your doctor may recommend a platelet transfusion or other supportive care. Tell your healthcare provider if you have any signs of low platelet counts, including bleeding and easy bruising.
•  Lowered white blood cells (neutropenia). VELCADE can cause low levels of neutrophils which are a type of white blood cell that help to fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection. You will have regular blood tests to check your cell counts during your treatment with VELCADE. If the number of these cells is very low, your doctor may change the dose and/or schedule of VELCADE.
•  Tumor Lysis Syndrome (TLS). TLS is caused by a fast breakdown of cancer cells. TLS can cause you to have kidney failure and the need for dialysis treatment and/or an abnormal heartbeat. Your healthcare provider may do blood tests to check for TLS.
•  Liver problems. If you have liver problems, it can be harder for your body to get rid of VELCADE. VELCADE has caused sudden liver failure in people who were taking many medications or had other serious medical conditions. Symptoms of liver problems include a yellow discoloration of the eyes and skin (jaundice) and pain in your right upper stomach-area. Your doctor will closely monitor you if you have liver disease. It is not known whether restarting VELCADE therapy in patients previously experiencing this complication is safe.
•  Hematologic disease (Thrombotic Microangiopathy, TMA). VELCADE can lead to the formation of blood clots in small blood vessels. These clots can result in low platelets, kidney damage, confusion, and an increased risk of bleeding, and may lead to death. Tell your doctor if you develop pinpoint-sized purple dots (petechiae), larger bruises, or if you see blood in your urine. Your doctor may stop treatment with VELCADE. It is not known whether restarting VELCADE therapy in patients previously experiencing this complication is safe.

The most commonly reported side effects in clinical studies include:

•  Nausea
•  Diarrhea
•  Low platelets (thrombocytopenia)
•  Decreased number of neutrophils, a type of white blood cell (neutropenia)
•  Nerve damage (peripheral neuropathy)
•  Fatigue
•  Nerve pain (neuralgia)
•  Low red blood cells (anemia)
•  Low white blood cells (leukopenia)
•  Constipation
•  Vomiting
•  Decreased number of lymphocytes, a type of white blood cell (lymphopenia)
•  Rash
•  Fever (pyrexia)
•  Lack of appetite (anorexia)

These are not all of the possible side effects with VELCADE. It is important to always contact your doctor if you experience any side effects while on VELCADE. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before you take VELCADE, tell your healthcare provider about all of your medical conditions, including if you:

•  have liver disease or kidney disease. If you are on dialysis, your doctor will administer VELCADE after the dialysis procedure.
•  are taking medication for diabetes. VELCADE can affect your blood glucose levels. Your doctor may require close monitoring of your blood glucose levels and change the dose of your diabetes medicine while you are being treated with VELCADE.
•  develop a rash of any type or have skin pain while receiving VELCADE.
•  are pregnant or plan to become pregnant. VELCADE can harm your unborn baby. Females who are able to become pregnant:
  •  Your healthcare provider will determine whether or not you are pregnant before you start treatment with VELCADE.
  •  Females who are able to become pregnant must use effective birth control during treatment and for seven months after your last dose of VELCADE.

  Males with females partners who are able to become pregnant:

  •  Males with female partners of reproductive potential must use effective contraception during treatment with VELCADE and for four months following the last dose of VELCADE.
•  Tell your healthcare provider right away if you or your partner become pregnant while you are receiving VELCADE or within seven months following the last dose.
•  VELCADE may have an effect on either male or female fertility.
•  are breastfeeding or plan to breastfeed. It is not known if VELCADE passes into breast milk, or if it affects an infant who is breastfed, or breast milk production. Do not breastfeed during treatment with VELCADE and for two months after your last dose of VELCADE.

Tell your healthcare provider about all the medicines you take, including prescription and over-the counter medicines, vitamins, and herbal supplements. VELCADE and other medicines may affect each other. Talk to your healthcare provider before starting any new medicines during treatment with VELCADE.

What should I avoid while taking VELCADE?

VELCADE may cause fatigue, dizziness, fainting (syncope), or lightheadedness when you sit or stand up. You should not drive or operate machinery if you experience any of these symptoms.

How is VELCADE administered?

VELCADE is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously, or IV) or under your skin (subcutaneously, or SC).