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Chemical Name: RIFAXIMIN (rif-AX-i-min)

XIFAXAN (Rifaximin) is a prescription antibiotic used to treat several different conditions. It can be used for the following:

  • Reduction of the occurrence of hepatic encephalopathy
  • Treatment of travelers’ diarrhea
  • Treatment of irritable bowel syndrome with diarrhea (IBS-D)

XIFAXAN is an antibacterial medication that works by binding to bacterial DNA-dependent RNA polymerase, preventing bacteria from replicating their DNA and preventing bacterial growth.

XIFAXAN is thought to reduce the occurrence of hepatic encephalopathy by inhibiting the growth of ammonia-producing bacteria.

XIFAXAN works in travelers’ diarrhea and IBS-D by preventing the growth of certain harmful bacteria.

Directions

XIFAXAN has different directions based on the condition being treated. Take it exactly as prescribed by your physician. That standard directions are:

  • Hepatic encephalopathy: Take one XIFAXAN 550 mg tablet by mouth twice daily.
  • Travelers’ diarrhea: Take one XIFAXAN 200 mg tablet by mouth three times daily for three days.
  • IBS-D: Take one XIFAXAN 550 mg tablet three times daily for 14 days. This regimen may be repeated up to two times as prescribed by the physician.

Ingredients

The active ingredient and name of the XIFAXAN generic is rifaximin.

The medication is available as XIFAXAN 200 mg tablets and XIFAXAN 550 mg tablets.

Cautions

If taking XIFAXAN for travelers’ diarrhea, it may not be effective for pathogens other than Escherichia coli (E. coli). If diarrhea does not improve within 24 to 48 hours after starting XIFAXAN, stop taking the medication and speak with your doctor about different antibiotic options.

Do not use XIFAXAN to treat diarrhea accompanied by fever or blood in the stool, as this may be a sign of Clostridium difficile-associated diarrhea.

If you have a history of liver damage or liver failure, speak with your doctor before starting XIFAXAN.

XIFAXAN has the potential for important drug interactions, especially with medications that are used to prevent organ transplant rejections. Speak with your doctor or pharmacist about your other medications before starting XIFAXAN.

Side Effects

Some of the most common side effects of XIFAXAN include:

  • Anorexia
  • Arthralgia
  • Decreased weight
  • Dizziness
  • Dysentery
  • Dyspnea
  • Nasal passage irritation
  • Nausea
  • Peripheral Edema
  • Pruritis
  • Pyrexia
  • Taste loss

Please speak with your doctor or pharmacist for a complete list of side effects. The side effects experienced may vary based on which condition is being treated and for how long the medication is being taken.

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