Angeliq contains a combination of drospirenone and estradiol. Drospirenone is a female hormone that helps regulate ovulation and menstruation. Estradiol is a female hormone involved in development and maintenance of the female reproductive system. Angeliq is used to treat the symptoms of menopause such as hot flashes or vaginal changes (itching, burning, dryness, urination problems). Angeliq is also used to prevent thinning of the bones (osteoporosis). Angeliq is also used to treat the symptoms of premenstrual dysphoric disorder (PMDD). The symptoms of PMDD include depression, anxiety, persistent anger or irritability, trouble concentrating, sleep or appetite changes, and feeling out of control. PMDD also includes physical symptoms such as breast tenderness, headache, joint or muscle pain, bloating, and weight gain. PMDD is not the same condition as premenstrual syndrome (PMS). Angeliq is not meant to treat PMS.