Arthrotec (Diclofenac/Misoprostol)




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What is Arthrotec and Uses:

Chemical Name DICLOFENAC (dye-KLOE-fen-ak) and MISOPROSTOL (mye-soe-PROST-ole)

Arthrotec (Diclofenac + Misoprostol)

Arthrotec 50 is used to relieve osteoarthritis and rheumatoid arthritis in people who are at high risk of developing stomach or intestinal ulcers and other complications from these ulcers. Arthrotec contains a combination of two substances called, diclofenac and misoprostol.

Diclofenac is an NSAID that stands for the non-steroidal anti-inflammatory drug. The function of diclofenac is to reduce pain, swelling, and joint stiffness due to arthritis. Misoprostol, on the other hand, protects the stomach from irritating effects of diclofenac by reducing the stomach acid and adding in protective substances.

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Take Arthrotec 70 by mouth with a full glass of water, at least about 8 ounces. It is advised to swallow the tablets as a whole. Avoid crushing, chewing, or dissolving the tablets as doing so can increase the risk of side effects.

You can also take this medication with meals to prevent stomach upsets and to reduce the chances of diarrhea.


Arthrotec 50 contains diclofenac and misoprostol as well as colloidal silicon dioxide. It also has other ingredients which are:

  • Crospovidone
  • Hydrogenated castor oil
  • Hypromellose, lactose
  • Magnesium stearate
  • Methacrylic acid copolymer
  • Microcrystalline cellulose
  • Povidone (polyvidone) K-30
  • Sodium hydroxide
  • Starch (corn)
  • Talc
  • Triethyl citrate.


  • Do not take tablets that are broken.
  • Do not lie down for at least 10 minutes after taking this medication.
  • Do not take this medicine if you’re pregnant.
  • Do not take this medicine if breastfeeding.
  • Not suitable for use by women of child-bearing age.
  • Kidney problems may occur
  • Avoid smoking and alcohol when taking this medicine.
  • The drug makes an individual sensitive to the sun, avoid going out in the sun or tanning booths when using Arthrotec 70.

Side Effects

There are a few side effects of this medicine. Therefore, it needs to be taken the correct way to minimize serious effects.

  • Abdominal pain
  • Diarrhea
  • Upset stomach
  • Heartburn
  • Drowsiness
  • Dizziness
  • Constipation

Inform your doctor if you notice any serious side effects as follows:

  • Abnormal vaginal bleeding
  • Menstrual problems
  • Swelling of hands and feet
  • Sudden weight gain